This gene encodes a member of the acyl-CoA dehydrogenase family. Members of this family of proteins localize to the mitochondria and catalyze the rate-limiting step in the beta-oxidation of fatty acyl-CoA. The encoded protein is specifically active toward palmitoyl-CoA and long-chain unsaturated substrates. Mutations in this gene cause acyl-CoA dehydrogenase family member type 9 deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for ACAD9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACAD9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACAD9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,581,519–128,582,200 | 297.8 kb | Distal (>10kb) Multiome | 16 | |
| chr3:128,607,947–128,608,800 | 271.2 kb | Distal (>10kb) Multiome | 376 | |
| chr3:128,617,357–128,618,496 | 261.9 kb | Distal (>10kb) Multiome HiCAR | 735 | |
| chr3:128,650,142–128,651,178 | 228.8 kb | Distal (>10kb) Multiome | 772 | |
| chr3:128,653,061–128,654,283 | 225.8 kb | Distal (>10kb) Multiome | 55 | |
| chr3:128,675,353–128,676,166 | 203.7 kb | Distal (>10kb) Multiome | 103 | |
| chr3:128,680,397–128,681,422 | 198.7 kb | Distal (>10kb) Multiome HiCAR | 1014 | |
| chr3:128,698,248–128,698,988 | 181.1 kb | Distal (>10kb) Multiome | 239 | |
| chr3:128,725,886–128,726,915 | 153.5 kb | Distal (>10kb) Multiome | 900 | |
| chr3:128,832,889–128,833,369 | 46.5 kb | Distal (>10kb) Multiome | 38 | |
| chr3:128,845,614–128,846,390 | 33.7 kb | Distal (>10kb) Multiome | 538 | |
| chr3:128,875,637–128,875,828 | 3.8 kb | Proximal (<10kb) | 160 | |
| chr3:128,878,828–128,880,293 | 88 bp | At TSS Multiome | 1016 | |
| chr3:128,993,367–128,994,455 | 114.4 kb | Distal (>10kb) Multiome | 344 | |
| chr3:129,027,026–129,027,525 | 147.6 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,045,697–129,046,752 | 167.0 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,120,244–129,122,947 | 242.4 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 281.7 kb | Distal (>10kb) Multiome | 917 |
Genomic view of the ACAD9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.