Predicted to enable structural molecule activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and cell-cell signaling. Located in cell surface and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MPZL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MPZL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MPZL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:167,439,212–167,439,960 | 282.4 kb | Distal (>10kb) Multiome | 362 | |
| chr1:167,454,695–167,456,365 | 266.9 kb | Distal (>10kb) Multiome | 569 | |
| chr1:167,489,386–167,490,223 | 232.1 kb | Distal (>10kb) Multiome | 134 | |
| chr1:167,526,635–167,527,418 | 195.0 kb | Distal (>10kb) Multiome | 77 | |
| chr1:167,533,465–167,534,246 | 188.1 kb | Distal (>10kb) Multiome | 260 | |
| chr1:167,553,117–167,554,407 | 168.2 kb | Distal (>10kb) Multiome | 811 | |
| chr1:167,713,429–167,715,919 | 6.4 kb | Proximal (<10kb) Multiome | 1144 | |
| chr1:167,716,321–167,716,922 | 5.4 kb | Proximal (<10kb) Multiome | 279 | |
| chr1:167,721,109–167,721,476 | 511 bp | At TSS | 283 | |
| chr1:167,721,587–167,722,654 | 34 bp | At TSS Multiome | 729 | |
| chr1:167,726,055–167,726,540 | 4.1 kb | Proximal (<10kb) | 21 | |
| chr1:167,726,823–167,726,978 | 4.8 kb | Proximal (<10kb) | 20 | |
| chr1:167,735,321–167,736,296 | 13.9 kb | Distal (>10kb) Multiome | 106 | |
| chr1:167,791,182–167,791,821 | 69.5 kb | Distal (>10kb) Multiome HiCAR | 97 | |
| chr1:167,803,184–167,803,921 | 81.5 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr1:167,819,954–167,820,473 | 98.3 kb | Distal (>10kb) Multiome | 410 | |
| chr1:167,822,319–167,822,995 | 100.7 kb | Distal (>10kb) Multiome | 107 | |
| chr1:167,856,829–167,857,439 | 135.2 kb | Distal (>10kb) Multiome | 62 | |
| chr1:167,935,207–167,937,689 | 214.4 kb | Distal (>10kb) Multiome HiCAR | 1086 |
Genomic view of the MPZL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.