DLST
dihydrolipoamide S-succinyltransferase | KGD2, OGDC-E2, DLTS

This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

Member of: DE-10 DE-10.1 Developmental clusters: GC4
Biological processes 32 terms
2-oxoglutarate decarboxylation to succinyl-CoA (GO:0120551)2-oxoglutarate metabolic process (GO:0006103)2-oxoglutarate metabolic process (GO:0006103)acyltransferase activity (GO:0016746)acyltransferase activity (GO:0016746)dihydrolipoyllysine-residue glutaryltransferase activity (GO:0120571)dihydrolipoyllysine-residue succinyltransferase activity (GO:0004149)dihydrolipoyllysine-residue succinyltransferase activity (GO:0004149)dihydrolipoyllysine-residue succinyltransferase activity (GO:0004149)dihydrolipoyllysine-residue succinyltransferase activity (GO:0004149)generation of precursor metabolites and energy (GO:0006091)membrane (GO:0016020)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)oxoadipate dehydrogenase complex (GO:0160167)oxoglutarate dehydrogenase complex (GO:0045252)oxoglutarate dehydrogenase complex (GO:0045252)protein binding (GO:0005515)succinyl-CoA metabolic process (GO:0006104)tricarboxylic acid cycle (GO:0006099)tricarboxylic acid cycle (GO:0006099)tricarboxylic acid cycle (GO:0006099)tricarboxylic acid cycle (GO:0006099)
Expression (TPM)
DLST — as a Regulated Gene

TFs regulating DLST 0 TFs

Transcription factors with Perturb-seq knockdown data for DLST. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DLST upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to DLST

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DLST, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr14:74,611,325–74,612,912 269.2 kb Distal (>10kb) Multiome 552
chr14:74,620,601–74,621,179 261.1 kb Distal (>10kb) Multiome 257
chr14:74,763,078–74,763,795 118.6 kb Distal (>10kb) Multiome 808
chr14:74,879,596–74,880,720 1.9 kb Proximal (<10kb) Multiome 108
chr14:74,881,522–74,882,475 34 bp At TSS Multiome 877
chr14:74,888,049–74,888,948 6.1 kb Proximal (<10kb) 257
chr14:74,922,804–74,923,467 41.3 kb Distal (>10kb) Multiome 458
chr14:74,955,358–74,956,099 73.7 kb Distal (>10kb) Multiome 457
chr14:74,980,538–74,981,185 99.0 kb Distal (>10kb) Multiome 205
chr14:75,002,395–75,003,398 120.9 kb Distal (>10kb) Multiome 767
chr14:75,050,911–75,051,628 169.4 kb Distal (>10kb) Multiome 749
chr14:75,063,590–75,064,414 182.1 kb Distal (>10kb) Multiome 518
chr14:75,069,008–75,070,183 187.6 kb Distal (>10kb) Multiome 874
chr14:75,126,669–75,127,381 245.1 kb Distal (>10kb) Multiome 888
chr14:75,176,098–75,177,235 294.9 kb Distal (>10kb) Multiome 975

Genome Browser

Genomic view of the DLST locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr14:74,601,325 – 75,187,235
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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