Enables cadherin binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to act upstream of or within isotype switching. Located in actin cytoskeleton; cytoplasm; and plasma membrane. Is active in postsynapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SWAP70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SWAP70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SWAP70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:9,363,967–9,364,851 | 299.6 kb | Distal (>10kb) Multiome | 1019 | |
| chr11:9,384,450–9,385,531 | 279.4 kb | Distal (>10kb) Multiome | 939 | |
| chr11:9,460,209–9,461,643 | 203.2 kb | Distal (>10kb) Multiome | 1040 | |
| chr11:9,572,794–9,575,580 | 88.8 kb | Distal (>10kb) Multiome | 1075 | |
| chr11:9,613,193–9,614,617 | 49.9 kb | Distal (>10kb) Multiome | 997 | |
| chr11:9,626,920–9,627,395 | 36.9 kb | Distal (>10kb) Multiome | 172 | |
| chr11:9,663,540–9,664,862 | 3 bp | At TSS Multiome | 597 | |
| chr11:9,757,927–9,759,329 | 94.2 kb | Distal (>10kb) Multiome | 865 | |
| chr11:9,922,650–9,923,161 | 258.9 kb | Distal (>10kb) Multiome | 154 | |
| chr11:10,351,409–10,352,676 | 687.9 kb | Distal (>10kb) Multiome HiCAR | 677 |
Genomic view of the SWAP70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.