This 34-gene module includes ERCC1, MAP2K2, GLUL, and TADA3, with top enrichment in nucleotide excision repair, DNA repair, and response to DNA damage. Knockdown of SOX17 activates this module, while knockdown of NANOG and OCT4 represses it. This suggests the module is normally suppressed by pluripotency factors and becomes active as cells commit to endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.