The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IGBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:69,503,545–69,505,167 | 629.4 kb | Distal (>10kb) Multiome HiCAR | 392 | |
| chrX:69,990,216–69,990,702 | 143.0 kb | Distal (>10kb) Multiome | 49 | |
| chrX:70,129,478–70,129,688 | 3.8 kb | Proximal (<10kb) | 8 | |
| chrX:70,133,101–70,133,613 | 118 bp | At TSS Multiome | 529 | |
| chrX:70,133,703–70,134,422 | 257 bp | At TSS | 439 | |
| chrX:70,289,676–70,290,592 | 156.6 kb | Distal (>10kb) Multiome | 481 |
Genomic view of the IGBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.