The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FKBP1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FKBP1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FKBP1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:23,925,864–23,928,023 | 122.6 kb | Distal (>10kb) Multiome | 1102 | |
| chr2:23,939,310–23,941,043 | 109.2 kb | Distal (>10kb) Multiome | 856 | |
| chr2:24,009,633–24,010,873 | 39.5 kb | Distal (>10kb) Multiome | 382 | |
| chr2:24,046,941–24,048,071 | 2.2 kb | Proximal (<10kb) Multiome | 719 | |
| chr2:24,049,244–24,050,644 | 9 bp | At TSS Multiome | 554 | |
| chr2:24,075,859–24,077,721 | 26.9 kb | Distal (>10kb) Multiome | 1100 | |
| chr2:24,083,513–24,085,355 | 34.7 kb | Distal (>10kb) Multiome | 1088 | |
| chr2:24,123,015–24,123,986 | 73.8 kb | Distal (>10kb) Multiome | 899 | |
| chr2:24,191,824–24,192,305 | 142.3 kb | Distal (>10kb) Multiome | 68 | |
| chr2:24,280,210–24,280,709 | 230.6 kb | Distal (>10kb) Multiome | 38 | |
| chr2:24,315,559–24,316,125 | 266.0 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the FKBP1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.