This 35-gene module contains HMGB1, HSP90AA1, STMN1, HSPA8, and RAN, with enrichment for spliceosomal complex components and mRNA splicing via transesterification reactions, as well as vesicle lumen and secretory granule lumen proteins involved in protein domain-specific and ubiquitin ligase binding. Knockdown of SOX17 and SETDB1 activates this module. Knockdown of SMARCC1, CNBP, and ARID1A represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.