This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for HSPA8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSPA8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSPA8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:122,843,093–122,844,055 | 218.7 kb | Distal (>10kb) Multiome | 284 | |
| chr11:122,882,666–122,883,545 | 179.1 kb | Distal (>10kb) Multiome | 409 | |
| chr11:122,976,845–122,977,850 | 84.8 kb | Distal (>10kb) Multiome | 198 | |
| chr11:122,981,561–122,982,103 | 80.2 kb | Distal (>10kb) Multiome | 237 | |
| chr11:122,984,138–122,985,025 | 77.6 kb | Distal (>10kb) Multiome | 184 | |
| chr11:123,053,787–123,054,259 | 7.9 kb | Proximal (<10kb) | 59 | |
| chr11:123,054,366–123,054,619 | 7.5 kb | Proximal (<10kb) | 236 | |
| chr11:123,054,736–123,054,990 | 7.1 kb | Proximal (<10kb) | 59 | |
| chr11:123,061,397–123,063,188 | 281 bp | At TSS Multiome | 997 | |
| chr11:123,108,059–123,109,666 | 47.1 kb | Distal (>10kb) Multiome | 58 | |
| chr11:123,166,097–123,166,614 | 104.1 kb | Distal (>10kb) Multiome | 131 | |
| chr11:123,168,860–123,170,139 | 107.8 kb | Distal (>10kb) Multiome | 127 | |
| chr11:123,194,428–123,196,820 | 134.2 kb | Distal (>10kb) Multiome | 388 | |
| chr11:123,261,339–123,261,812 | 199.5 kb | Distal (>10kb) Multiome HiCAR | 295 | |
| chr11:123,301,675–123,302,413 | 239.8 kb | Distal (>10kb) Multiome | 385 |
Genomic view of the HSPA8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.