HSP90AA1

heat shock protein 90 alpha family class A member 1 | FLJ31884, HSP90N, Hsp89, Hsp90, HSPC1, HSPCA, HSPCAL4

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Member of: DE-1 DE-1.7 Developmental clusters: GC5

Biological processes 160 terms

AP-3 adaptor complex binding (GO:0035651)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP hydrolysis activity (GO:0016887)ATP-dependent protein folding chaperone (GO:0140662)CTP binding (GO:0002135)DNA polymerase binding (GO:0070182)DNA polymerase binding (GO:0070182)GTP binding (GO:0005525)GTPase binding (GO:0051020)MHC class II protein complex binding (GO:0023026)RNA binding (GO:0003723)Rho GDP-dissociation inhibitor binding (GO:0051022)TPR domain binding (GO:0030911)TPR domain binding (GO:0030911)UTP binding (GO:0002134)activation of innate immune response (GO:0002218)apical plasma membrane (GO:0016324)axonal growth cone (GO:0044295)axonal growth cone (GO:0044295)basolateral plasma membrane (GO:0016323)brush border membrane (GO:0031526)cardiac muscle cell apoptotic process (GO:0010659)cell surface (GO:0009986)cellular response to heat (GO:0034605)cellular response to heat (GO:0034605)cellular response to hydrogen peroxide (GO:0070301)cellular response to hypoxia (GO:0071456)cellular response to lipopolysaccharide (GO:0071222)cellular response to mechanical stimulus (GO:0071260)cellular response to platelet-derived growth factor stimulus (GO:0036120)cellular response to virus (GO:0098586)chaperone-mediated autophagy (GO:0061684)chaperone-mediated protein complex assembly (GO:0051131)chaperone-mediated protein complex assembly (GO:0051131)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)dATP binding (GO:0032564)dendritic growth cone (GO:0044294)dendritic growth cone (GO:0044294)disordered domain specific binding (GO:0097718)disordered domain specific binding (GO:0097718)endocytic vesicle lumen (GO:0071682)enzyme-substrate adaptor activity (GO:0140767)extracellular exosome (GO:0070062)extracellular matrix (GO:0031012)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)ficolin-1-rich granule lumen (GO:1904813)histone deacetylase binding (GO:0042826)histone deacetylase binding (GO:0042826)identical protein binding (GO:0042802)identical protein binding (GO:0042802)identical protein binding (GO:0042802)lysosomal lumen (GO:0043202)mRNA binding (GO:0003729)melanosome (GO:0042470)membrane (GO:0016020)mitochondrial transport (GO:0006839)mitochondrion (GO:0005739)mitochondrion (GO:0005739)myelin sheath (GO:0043209)myelin sheath (GO:0043209)negative regulation of striated muscle cell apoptotic process (GO:0010664)neurofibrillary tangle assembly (GO:1902988)neuron migration (GO:0001764)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)nitric oxide metabolic process (GO:0046209)nitric-oxide synthase regulator activity (GO:0030235)nitric-oxide synthase regulator activity (GO:0030235)nitric-oxide synthase regulator activity (GO:0030235)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cardiac muscle contraction (GO:0060452)positive regulation of cell size (GO:0045793)positive regulation of defense response to virus by host (GO:0002230)positive regulation of interferon-beta production (GO:0032728)positive regulation of lamellipodium assembly (GO:0010592)positive regulation of nitric oxide biosynthetic process (GO:0045429)positive regulation of nitric oxide biosynthetic process (GO:0045429)positive regulation of protein catabolic process (GO:0045732)positive regulation of protein import into nucleus (GO:0042307)positive regulation of protein polymerization (GO:0032273)positive regulation of telomere maintenance via telomerase (GO:0032212)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone complex (GO:0101031)protein folding chaperone complex (GO:0101031)protein homodimerization activity (GO:0042803)protein import into mitochondrial matrix (GO:0030150)protein maturation (GO:0051604)protein phosphatase binding (GO:0019903)protein refolding (GO:0042026)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein tyrosine kinase binding (GO:1990782)protein unfolding (GO:0043335)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)regulation of apoptotic process (GO:0042981)regulation of postsynaptic membrane neurotransmitter receptor levels (GO:0099072)regulation of protein localization (GO:0032880)regulation of protein localization (GO:0032880)regulation of protein ubiquitination (GO:0031396)regulation of protein ubiquitination (GO:0031396)regulation of protein-containing complex assembly (GO:0043254)response to antibiotic (GO:0046677)response to caloric restriction (GO:0061771)response to cocaine (GO:0042220)response to cold (GO:0009409)response to dietary excess (GO:0002021)response to estrogen (GO:0043627)response to follicle-stimulating hormone (GO:0032354)response to heat (GO:0009408)response to isolation stress (GO:0035900)response to salt stress (GO:0009651)response to unfolded protein (GO:0006986)response to xenobiotic stimulus (GO:0009410)scaffold protein binding (GO:0097110)secretory granule lumen (GO:0034774)secretory granule lumen (GO:0034774)skeletal muscle contraction (GO:0003009)sperm flagellum (GO:0036126)sperm mitochondrial sheath (GO:0097226)sperm plasma membrane (GO:0097524)sulfonylurea receptor binding (GO:0017098)tau protein binding (GO:0048156)tau protein binding (GO:0048156)telomerase holoenzyme complex assembly (GO:1905323)telomerase holoenzyme complex assembly (GO:1905323)telomere maintenance via telomerase (GO:0007004)telomere maintenance via telomerase (GO:0007004)transmembrane transporter binding (GO:0044325)ubiquitin protein ligase binding (GO:0031625)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating HSP90AA1 0 TFs

Transcription factors with Perturb-seq knockdown data for HSP90AA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HSP90AA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HSP90AA1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HSP90AA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:101,809,684–101,810,434	277.0 kb	Distal (>10kb) Multiome	701
chr14:101,947,631–101,948,934	138.8 kb	Distal (>10kb) Multiome	984
chr14:101,963,949–101,965,702	122.6 kb	Distal (>10kb) Multiome	798
chr14:102,046,172–102,046,761	40.5 kb	Distal (>10kb) Multiome	326
chr14:102,086,286–102,088,835	139 bp	At TSS Multiome	1052
chr14:102,096,661–102,096,836	9.6 kb	Proximal (<10kb)	273
chr14:102,097,398–102,098,067	10.7 kb	Distal (>10kb) Multiome	159
chr14:102,139,026–102,140,960	52.6 kb	Distal (>10kb) Multiome	844
chr14:102,247,845–102,248,746	161.4 kb	Distal (>10kb) Multiome	142
chr14:102,304,511–102,305,687	218.1 kb	Distal (>10kb) Multiome	568
chr14:102,314,028–102,314,685	227.3 kb	Distal (>10kb) Multiome	720
chr14:102,316,590–102,317,741	230.1 kb	Distal (>10kb) Multiome	885
chr14:102,319,368–102,320,458	232.7 kb	Distal (>10kb) Multiome	675
chr14:102,362,620–102,363,583	276.0 kb	Distal (>10kb) Multiome	705

Genome Browser

Genomic view of the HSP90AA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.