This 12-gene module includes RALA, UBE2N, GSPT1, UFD1, and UBE2D1, with enrichment in ubiquitin-dependent protein catabolic processes and translation termination. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN, MIXL1, and GATA4 repress it. This pattern suggests the module represents housekeeping functions in protein quality control that are suppressed during endoderm specification.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.