The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RALA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:39,353,499–39,355,182 | 269.7 kb | Distal (>10kb) Multiome | 344 | |
| chr7:39,413,990–39,414,973 | 209.0 kb | Distal (>10kb) Multiome | 460 | |
| chr7:39,566,027–39,566,876 | 57.2 kb | Distal (>10kb) Multiome | 879 | |
| chr7:39,622,891–39,624,257 | 46 bp | At TSS Multiome | 867 | |
| chr7:39,732,821–39,734,237 | 109.8 kb | Distal (>10kb) Multiome | 702 | |
| chr7:39,833,196–39,834,329 | 209.9 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the RALA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.