This 12-gene module includes FKBP1A, RNF7, ECHS1, RAB34, and UFC1, with top enriched terms related to protein folding, ubiquitin conjugation, and proteasomal degradation. Knockdown of SMAD3 activates this module. No TFs were identified whose knockdown represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.