TOMM22

translocase of outer mitochondrial membrane 22 | TOM22

The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.41 Developmental clusters: GC5

Biological processes 20 terms

intracellular protein transport (GO:0006886)membrane (GO:0016020)membrane (GO:0016020)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane (GO:0005741)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrial outer membrane translocase complex (GO:0005742)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion targeting sequence binding (GO:0030943)protein binding (GO:0005515)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein insertion into mitochondrial outer membrane (GO:0045040)protein localization to mitochondrion (GO:0070585)transmembrane protein transporter activity (GO:0008320)transmembrane protein transporter activity (GO:0008320)transmembrane protein transporter activity (GO:0008320)

Expression (TPM)

TFs regulating TOMM22 0 TFs

Transcription factors with Perturb-seq knockdown data for TOMM22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TOMM22

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:38,397,757–38,399,352	283.0 kb	Distal (>10kb) Multiome	345
chr22:38,455,555–38,456,345	225.9 kb	Distal (>10kb) Multiome	403
chr22:38,461,291–38,461,848	220.3 kb	Distal (>10kb) Multiome	595
chr22:38,505,466–38,506,961	175.5 kb	Distal (>10kb) Multiome	889
chr22:38,569,664–38,571,256	111.6 kb	Distal (>10kb) Multiome	559
chr22:38,655,982–38,657,104	25.5 kb	Distal (>10kb) Multiome	698
chr22:38,681,730–38,682,262	30 bp	At TSS Multiome	947
chr22:38,700,377–38,701,744	19.0 kb	Distal (>10kb) Multiome	916
chr22:38,705,151–38,706,595	23.7 kb	Distal (>10kb) Multiome	821
chr22:38,755,428–38,756,383	74.1 kb	Distal (>10kb) Multiome	770
chr22:38,793,674–38,794,378	112.2 kb	Distal (>10kb) Multiome	484
chr22:38,843,207–38,844,443	161.9 kb	Distal (>10kb) Multiome	585
chr22:38,866,394–38,866,832	184.6 kb	Distal (>10kb) Multiome	76
chr22:38,871,208–38,873,237	190.4 kb	Distal (>10kb) Multiome	758

Genome Browser

Genomic view of the TOMM22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.