This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for RAB34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,466,531–28,467,034 | 251.6 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 165.8 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 146.9 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 141.4 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 119.3 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 96.1 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 73.2 kb | Distal (>10kb) Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 56.3 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 7.0 kb | Proximal (<10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 542 bp | At TSS Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 1.4 kb | Proximal (<10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 8.6 kb | Proximal (<10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 25.6 kb | Distal (>10kb) Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 27.2 kb | Distal (>10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 31.8 kb | Distal (>10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 94.1 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 124.4 kb | Distal (>10kb) Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 136.5 kb | Distal (>10kb) Multiome | 780 | |
| chr17:28,896,962–28,898,028 | 179.2 kb | Distal (>10kb) Multiome | 846 | |
| chr17:28,902,302–28,903,488 | 184.6 kb | Distal (>10kb) Multiome | 967 | |
| chr17:28,950,281–28,952,708 | 233.2 kb | Distal (>10kb) Multiome | 989 | |
| chr17:28,984,463–28,984,954 | 266.2 kb | Distal (>10kb) Multiome | 33 | |
| chr17:28,985,971–28,986,457 | 267.8 kb | Distal (>10kb) Multiome | 123 | |
| chr17:29,005,841–29,006,414 | 287.6 kb | Distal (>10kb) Multiome | 707 |
Genomic view of the RAB34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.