Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for COX7A2L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX7A2L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX7A2L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:42,063,372–42,064,229 | 297.3 kb | Distal (>10kb) Multiome | 198 | |
| chr2:42,100,746–42,103,242 | 258.4 kb | Distal (>10kb) Multiome | 703 | |
| chr2:42,132,557–42,133,741 | 228.0 kb | Distal (>10kb) Multiome | 986 | |
| chr2:42,141,041–42,142,131 | 219.5 kb | Distal (>10kb) Multiome | 699 | |
| chr2:42,168,640–42,170,239 | 191.9 kb | Distal (>10kb) Multiome | 913 | |
| chr2:42,183,806–42,184,606 | 177.0 kb | Distal (>10kb) Multiome | 233 | |
| chr2:42,196,297–42,197,267 | 164.5 kb | Distal (>10kb) Multiome | 571 | |
| chr2:42,360,768–42,362,053 | 299 bp | At TSS Multiome | 866 | |
| chr2:42,492,549–42,495,300 | 132.8 kb | Distal (>10kb) Multiome | 920 | |
| chr2:42,545,606–42,546,387 | 184.9 kb | Distal (>10kb) Multiome | 211 | |
| chr2:42,567,798–42,569,119 | 207.3 kb | Distal (>10kb) Multiome | 598 | |
| chr2:42,792,290–42,793,678 | 431.6 kb | Distal (>10kb) Multiome HiCAR | 808 | |
| chr2:42,809,783–42,811,471 | 449.1 kb | Distal (>10kb) Multiome HiCAR | 1125 |
Genomic view of the COX7A2L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.