The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for FKBP1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FKBP1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FKBP1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:1,118,327–1,119,071 | 274.6 kb | Distal (>10kb) Multiome | 1066 | |
| chr20:1,184,818–1,186,197 | 207.4 kb | Distal (>10kb) Multiome | 557 | |
| chr20:1,225,365–1,226,806 | 167.3 kb | Distal (>10kb) Multiome | 616 | |
| chr20:1,266,029–1,266,958 | 126.7 kb | Distal (>10kb) Multiome | 499 | |
| chr20:1,300,911–1,301,500 | 91.9 kb | Distal (>10kb) Multiome | 171 | |
| chr20:1,313,163–1,313,790 | 79.6 kb | Distal (>10kb) Multiome | 428 | |
| chr20:1,325,008–1,326,107 | 67.7 kb | Distal (>10kb) Multiome | 901 | |
| chr20:1,391,813–1,391,980 | 1.2 kb | Proximal (<10kb) | 147 | |
| chr20:1,392,628–1,393,457 | 52 bp | At TSS Multiome | 799 | |
| chr20:1,427,438–1,428,145 | 34.6 kb | Distal (>10kb) Multiome | 285 | |
| chr20:1,466,316–1,467,471 | 73.7 kb | Distal (>10kb) Multiome | 1054 |
Genomic view of the FKBP1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.