UFC1

ubiquitin-fold modifier conjugating enzyme 1 | HSPC155

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

Member of: DE-1 DE-1.41

Biological processes 20 terms

UFM1 conjugating enzyme activity (GO:0061657)UFM1 conjugating enzyme activity (GO:0061657)UFM1 conjugating enzyme activity (GO:0061657)UFM1 transferase activity (GO:0071568)brain development (GO:0007420)cytoplasm (GO:0005737)extracellular exosome (GO:0070062)protein K69-linked ufmylation (GO:1990592)protein binding (GO:0005515)protein ufmylation (GO:0071569)protein ufmylation (GO:0071569)protein ufmylation (GO:0071569)protein ufmylation (GO:0071569)regulation of type II interferon production (GO:0032649)regulation of type II interferon production (GO:0032649)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)reticulophagy (GO:0061709)reticulophagy (GO:0061709)

Expression (TPM)

TFs regulating UFC1 0 TFs

Transcription factors with Perturb-seq knockdown data for UFC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UFC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to UFC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UFC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:160,910,331–160,911,177	243.3 kb	Distal (>10kb) Multiome	97
chr1:160,947,055–160,947,669	206.6 kb	Distal (>10kb) Multiome	35
chr1:160,948,561–160,949,851	204.6 kb	Distal (>10kb) Multiome	173
chr1:160,981,323–160,982,552	172.2 kb	Distal (>10kb) Multiome	156
chr1:161,020,536–161,021,920	132.7 kb	Distal (>10kb) Multiome	846
chr1:161,038,489–161,039,130	115.0 kb	Distal (>10kb) Multiome	468
chr1:161,045,080–161,046,516	108.0 kb	Distal (>10kb) Multiome	927
chr1:161,097,691–161,099,047	55.7 kb	Distal (>10kb) Multiome	829
chr1:161,117,504–161,118,419	35.9 kb	Distal (>10kb) Multiome	794
chr1:161,131,760–161,133,351	21.3 kb	Distal (>10kb) Multiome	956
chr1:161,153,700–161,154,461	46 bp	At TSS Multiome	816
chr1:161,158,928–161,160,167	5.5 kb	Proximal (<10kb) Multiome	706
chr1:161,165,740–161,167,170	12.4 kb	Distal (>10kb) Multiome	888
chr1:161,176,874–161,177,972	23.5 kb	Distal (>10kb) Multiome	910
chr1:161,198,215–161,199,209	44.6 kb	Distal (>10kb) Multiome	357
chr1:161,201,572–161,202,783	48.3 kb	Distal (>10kb) Multiome	852
chr1:161,225,326–161,226,910	71.9 kb	Distal (>10kb) Multiome	710
chr1:161,227,235–161,227,802	73.6 kb	Distal (>10kb) Multiome	372
chr1:161,258,515–161,259,098	104.8 kb	Distal (>10kb) Multiome	281
chr1:161,305,737–161,306,708	152.3 kb	Distal (>10kb) Multiome	430
chr1:161,313,977–161,314,703	160.4 kb	Distal (>10kb) Multiome	824
chr1:161,389,675–161,390,784	236.2 kb	Distal (>10kb) Multiome	866
chr1:161,399,098–161,400,259	245.7 kb	Distal (>10kb) Multiome	1040

Genome Browser

Genomic view of the UFC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.