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DE-1.39

Submodule 13 genes

Hypoxia response and cytoskeletal dynamics

This 13-gene module includes FOXC1, FADD, EGLN2, PFN2, and PGD, with enrichment in hypoxia response, apoptosis regulation, and actin cytoskeleton organization. Knockdown of SOX17 activates this module. No TFs show repression of this module in the dataset.

Key terms: regulation of osteoclast proliferation positive regulation of leukocyte proliferation regulation of activation-induced cell death of T cells regulation of macromolecule metabolic process Notable genes: FOXC1 FADD EGLN2 PFN2 PGD NMB FBXW5 HOMER3 Top TFs: SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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