This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for NMB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NMB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NMB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:84,570,159–84,571,300 | 87.3 kb | Distal (>10kb) Multiome | 730 | |
| chr15:84,587,808–84,588,502 | 70.0 kb | Distal (>10kb) Multiome | 357 | |
| chr15:84,600,331–84,601,554 | 57.2 kb | Distal (>10kb) Multiome | 827 | |
| chr15:84,603,386–84,604,192 | 54.4 kb | Distal (>10kb) Multiome HiCAR | 119 | |
| chr15:84,630,983–84,631,898 | 26.9 kb | Distal (>10kb) Multiome | 649 | |
| chr15:84,633,275–84,634,337 | 24.4 kb | Distal (>10kb) Multiome | 621 | |
| chr15:84,653,715–84,654,595 | 3.8 kb | Proximal (<10kb) Multiome | 788 | |
| chr15:84,654,705–84,655,032 | 3.2 kb | Proximal (<10kb) | 393 | |
| chr15:84,657,788–84,658,916 | 170 bp | At TSS Multiome | 591 | |
| chr15:84,659,709–84,660,001 | 1.5 kb | Proximal (<10kb) | 26 | |
| chr15:84,715,472–84,717,226 | 58.1 kb | Distal (>10kb) Multiome | 972 | |
| chr15:84,734,887–84,735,749 | 77.0 kb | Distal (>10kb) Multiome | 614 | |
| chr15:84,747,459–84,749,457 | 90.3 kb | Distal (>10kb) Multiome | 852 | |
| chr15:84,816,861–84,818,557 | 159.6 kb | Distal (>10kb) Multiome HiCAR | 375 | |
| chr15:84,928,071–84,928,522 | 270.2 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the NMB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.