The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PFN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PFN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PFN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:149,716,922–149,717,701 | 253.5 kb | Distal (>10kb) Multiome | 161 | |
| chr3:149,752,004–149,753,499 | 218.2 kb | Distal (>10kb) Multiome | 991 | |
| chr3:149,812,342–149,813,957 | 157.8 kb | Distal (>10kb) Multiome | 918 | |
| chr3:149,969,248–149,969,512 | 1.4 kb | Proximal (<10kb) | 338 | |
| chr3:149,969,831–149,971,970 | 325 bp | At TSS Multiome | 920 | |
| chr3:149,976,043–149,976,210 | 5.1 kb | Proximal (<10kb) | 28 | |
| chr3:150,097,150–150,098,142 | 126.7 kb | Distal (>10kb) Multiome | 220 | |
| chr3:150,130,019–150,131,345 | 159.6 kb | Distal (>10kb) Multiome HiCAR | 166 | |
| chr3:150,165,261–150,165,994 | 194.8 kb | Distal (>10kb) Multiome HiCAR | 106 | |
| chr3:150,215,844–150,216,844 | 245.4 kb | Distal (>10kb) Multiome HiCAR | 265 |
Genomic view of the PFN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.