EGLN2

egl-9 family hypoxia inducible factor 2 | HIFPH1, PHD1

The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]

Member of: DE-1 DE-1.39

Biological processes 28 terms

2-oxoglutarate-dependent dioxygenase activity (GO:0016706)L-ascorbic acid binding (GO:0031418)cell redox homeostasis (GO:0045454)cellular response to hypoxia (GO:0071456)cytoplasm (GO:0005737)estrogen receptor signaling pathway (GO:0030520)ferrous iron binding (GO:0008198)ferrous iron binding (GO:0008198)ferrous iron binding (GO:0008198)hypoxia-inducible factor-proline dioxygenase activity (GO:0160082)iron ion binding (GO:0005506)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (GO:0016705)oxygen sensor activity (GO:0019826)peptidyl-proline 4-dioxygenase activity (GO:0031545)peptidyl-proline 4-dioxygenase activity (GO:0031545)peptidyl-proline 4-dioxygenase activity (GO:0031545)peptidyl-proline hydroxylation to 4-hydroxy-L-proline (GO:0018401)positive regulation of protein catabolic process (GO:0045732)protein binding (GO:0005515)regulation of cell growth (GO:0001558)regulation of neuron apoptotic process (GO:0043523)regulation of neuron apoptotic process (GO:0043523)response to hypoxia (GO:0001666)

Expression (TPM)

TFs regulating EGLN2 0 TFs

Transcription factors with Perturb-seq knockdown data for EGLN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EGLN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to EGLN2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EGLN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:40,519,457–40,519,993	279.9 kb	Distal (>10kb) Multiome	222
chr19:40,528,978–40,529,879	270.2 kb	Distal (>10kb) Multiome	601
chr19:40,529,987–40,530,863	268.9 kb	Distal (>10kb) Multiome	384
chr19:40,549,036–40,549,555	250.2 kb	Distal (>10kb) Multiome	372
chr19:40,570,181–40,571,253	228.8 kb	Distal (>10kb) Multiome	598
chr19:40,576,133–40,577,495	222.7 kb	Distal (>10kb) Multiome	616
chr19:40,596,828–40,597,429	202.5 kb	Distal (>10kb) Multiome	354
chr19:40,598,094–40,598,871	201.0 kb	Distal (>10kb) Multiome	606
chr19:40,603,345–40,604,624	195.5 kb	Distal (>10kb) Multiome	889
chr19:40,604,983–40,606,597	193.8 kb	Distal (>10kb) Multiome	708
chr19:40,609,543–40,610,691	189.5 kb	Distal (>10kb) Multiome	519
chr19:40,612,884–40,615,179	185.9 kb	Distal (>10kb) Multiome	595
chr19:40,623,557–40,624,516	175.5 kb	Distal (>10kb) Multiome	454
chr19:40,634,333–40,634,959	164.9 kb	Distal (>10kb) Multiome	629
chr19:40,662,838–40,663,654	136.5 kb	Distal (>10kb) Multiome	856
chr19:40,689,888–40,691,759	108.8 kb	Distal (>10kb) Multiome	691
chr19:40,714,822–40,715,454	84.4 kb	Distal (>10kb) Multiome	531
chr19:40,716,605–40,717,875	82.5 kb	Distal (>10kb) Multiome	772
chr19:40,750,206–40,751,874	48.7 kb	Distal (>10kb) Multiome	989
chr19:40,777,237–40,779,173	21.3 kb	Distal (>10kb) Multiome	901
chr19:40,798,002–40,799,843	554 bp	At TSS Multiome	936
chr19:40,806,580–40,807,205	7.4 kb	Proximal (<10kb) Multiome	496
chr19:40,810,733–40,811,261	11.4 kb	Distal (>10kb) Multiome	115

Genome Browser

Genomic view of the EGLN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.