The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for FADD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FADD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FADD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:69,048,479–69,049,470 | 1154.4 kb | Distal (>10kb) Multiome HiCAR | 583 | |
| chr11:70,078,428–70,079,018 | 124.5 kb | Distal (>10kb) Multiome | 150 | |
| chr11:70,141,113–70,142,538 | 61.6 kb | Distal (>10kb) Multiome | 319 | |
| chr11:70,196,165–70,196,382 | 6.9 kb | Proximal (<10kb) | 214 | |
| chr11:70,202,749–70,203,803 | 72 bp | At TSS Multiome | 782 | |
| chr11:70,207,434–70,207,854 | 4.1 kb | Proximal (<10kb) | 39 | |
| chr11:70,213,835–70,214,626 | 10.9 kb | Distal (>10kb) Multiome | 51 | |
| chr11:70,219,601–70,220,630 | 16.8 kb | Distal (>10kb) Multiome | 148 | |
| chr11:70,269,844–70,271,534 | 67.3 kb | Distal (>10kb) Multiome | 790 | |
| chr11:70,397,703–70,399,001 | 195.2 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the FADD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.