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DE-1.38

Submodule 13 genes

Vesicle trafficking and protein transport functions

This module contains 13 genes including VPS35, MED19, NELFE, LSR, and SAMM50, with enrichment in vesicle trafficking, protein transport, and related cellular processes. Knockdown of ZC3H3, DNAJC19, and SOX17 activates this module. No repressing TFs are reported for this module.

Key terms: negative regulation of vacuolar transport tricarboxylic acid cycle retrograde axonal transport of mitochondrion tricellular tight junction assembly Notable genes: VPS35 MED19 NELFE LSR SAMM50 CCNDBP1 DRG1 SUCLG1 Top TFs: ZC3H3 DNAJC19 SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (13)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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