The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for MED19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,426,113–57,427,448 | 285.1 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 254.8 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 251.6 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 231.7 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 229.1 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 218.5 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 212.4 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 197.8 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 181.3 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 144.1 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 114.1 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 74.0 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 67.3 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,646,682–57,652,802 | 62.3 kb | Distal (>10kb) Multiome | 580 | |
| chr11:57,656,843–57,658,231 | 54.6 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 44.4 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 35 bp | At TSS Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 29.2 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 49.5 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 66.5 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 69.4 kb | Distal (>10kb) Multiome | 317 | |
| chr11:57,800,273–57,801,159 | 88.5 kb | Distal (>10kb) Multiome | 547 | |
| chr11:57,902,618–57,904,039 | 191.1 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the MED19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.