Predicted to be involved in several processes, including establishment of skin barrier; protein localization to tricellular tight junction; and tricellular tight junction assembly. Predicted to act upstream of or within maintenance of blood-brain barrier. Located in plasma membrane and tight junction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LSR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:34,963,909–34,964,414 | 284.8 kb | Distal (>10kb) Multiome | 645 | |
| chr19:34,999,304–35,000,970 | 248.8 kb | Distal (>10kb) Multiome | 759 | |
| chr19:35,030,124–35,031,270 | 218.4 kb | Distal (>10kb) Multiome | 534 | |
| chr19:35,040,969–35,041,953 | 207.4 kb | Distal (>10kb) Multiome | 806 | |
| chr19:35,055,754–35,056,570 | 193.0 kb | Distal (>10kb) Multiome | 268 | |
| chr19:35,066,952–35,067,448 | 181.8 kb | Distal (>10kb) Multiome | 497 | |
| chr19:35,067,923–35,068,779 | 180.3 kb | Distal (>10kb) Multiome | 190 | |
| chr19:35,090,562–35,091,150 | 158.2 kb | Distal (>10kb) Multiome | 303 | |
| chr19:35,135,242–35,135,695 | 113.5 kb | Distal (>10kb) Multiome | 525 | |
| chr19:35,140,763–35,141,948 | 107.6 kb | Distal (>10kb) Multiome | 509 | |
| chr19:35,142,085–35,143,541 | 106.0 kb | Distal (>10kb) Multiome | 328 | |
| chr19:35,154,641–35,155,298 | 93.9 kb | Distal (>10kb) Multiome | 552 | |
| chr19:35,247,580–35,249,688 | 239 bp | At TSS Multiome | 1088 | |
| chr19:35,253,873–35,254,186 | 4.9 kb | Proximal (<10kb) | 250 | |
| chr19:35,266,852–35,270,128 | 20.7 kb | Distal (>10kb) Multiome | 869 | |
| chr19:35,471,034–35,471,539 | 222.3 kb | Distal (>10kb) Multiome | 15 | |
| chr19:35,509,786–35,510,900 | 261.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 296.6 kb | Distal (>10kb) Multiome | 879 |
Genomic view of the LSR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.