This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for SUCLG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUCLG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUCLG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:84,386,149–84,387,160 | 72.7 kb | Distal (>10kb) Multiome | 233 | |
| chr2:84,458,550–84,460,090 | 91 bp | At TSS Multiome | 901 | |
| chr2:84,461,804–84,462,404 | 2.5 kb | Proximal (<10kb) | 54 | |
| chr2:84,515,862–84,516,845 | 57.1 kb | Distal (>10kb) Multiome | 353 | |
| chr2:84,578,343–84,579,264 | 119.5 kb | Distal (>10kb) Multiome | 126 | |
| chr2:84,904,641–84,908,593 | 448.1 kb | Distal (>10kb) Multiome HiCAR | 1075 |
Genomic view of the SUCLG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.