Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for DRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:31,104,824–31,105,447 | 294.5 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 291.9 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 272.1 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 259.1 kb | Distal (>10kb) Multiome | 244 | |
| chr22:31,160,052–31,160,698 | 239.4 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 187.4 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 108.8 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,345,143–31,347,910 | 53.5 kb | Distal (>10kb) Multiome | 954 | |
| chr22:31,362,564–31,363,231 | 36.8 kb | Distal (>10kb) Multiome | 164 | |
| chr22:31,399,166–31,400,036 | 111 bp | At TSS Multiome | 913 | |
| chr22:31,489,111–31,490,354 | 90.3 kb | Distal (>10kb) Multiome | 819 | |
| chr22:31,496,060–31,496,942 | 96.9 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,630,284–31,631,283 | 231.2 kb | Distal (>10kb) Multiome | 643 | |
| chr22:31,661,894–31,662,649 | 262.6 kb | Distal (>10kb) Multiome | 791 | |
| chr22:31,676,686–31,677,164 | 277.3 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the DRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.