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DE-1.3

Submodule 56 genes

GDP binding and unfolded protein response

This 56-gene module includes KRAS, BAK1, SDHB, PRKAR1A, and TSG101, with strong enrichment for GDP binding and guanyl nucleotide binding functions, along with cellular stress responses including unfolded protein handling and positive regulation of macroautophagy. No transcription factor knockdown data are available for this module.

Key terms: response to unfolded protein response to topologically incorrect protein positive regulation of macroautophagy regulation of IRE1-mediated unfolded protein response Notable genes: KRAS BAK1 SDHB PRKAR1A TSG101 PDCD10 SDCBP THAP1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (56)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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