SDHB

succinate dehydrogenase complex iron sulfur subunit B | SDH, SDH1

This tumor suppressor gene encodes the iron-sulfur protein subunit of the succinate dehydrogenase (SDH) enzyme complex which plays a critical role in mitochondria. The SDH enzyme complex is composed of four nuclear-encoded subunits. This enzyme complex converts succinate to fumarate which releases electrons as part of the citric acid cycle, and the enzyme complex additionally provides an attachment site for released electrons to be transferred to the oxidative phosphorylation pathway. The SDH enzyme complex plays a role in oxygen-related gene regulation through its conversion of succinate, which is an oxygen sensor that stabilizes the hypoxia-inducible factor 1 (HIF1) transcription factor. Sporadic and familial mutations in this gene result in paragangliomas, pheochromocytoma, and gastrointestinal stromal tumors, supporting a link between mitochondrial dysfunction and tumorigenesis. Mutations in this gene are also implicated in nuclear type 4 mitochondrial complex II deficiency. [provided by RefSeq, Jun 2022]

Member of: DE-1 DE-1.3 Developmental clusters: GC5

Biological processes 36 terms

2 iron, 2 sulfur cluster binding (GO:0051537)2 iron, 2 sulfur cluster binding (GO:0051537)3 iron, 4 sulfur cluster binding (GO:0051538)4 iron, 4 sulfur cluster binding (GO:0051539)aerobic respiration (GO:0009060)aerobic respiration (GO:0009060)electron transfer activity (GO:0009055)iron-sulfur cluster binding (GO:0051536)mitochondrial electron transport, succinate to ubiquinone (GO:0006121)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial membrane (GO:0031966)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)oxidoreductase activity (GO:0016491)protein binding (GO:0005515)proton motive force-driven mitochondrial ATP synthesis (GO:0042776)respiratory chain complex II (succinate dehydrogenase) (GO:0045273)respiratory chain complex II (succinate dehydrogenase) (GO:0045273)respiratory chain complex II (succinate dehydrogenase) (GO:0045273)respiratory electron transport chain (GO:0022904)respiratory electron transport chain (GO:0022904)succinate dehydrogenase (quinone) activity (GO:0008177)succinate dehydrogenase (quinone) activity (GO:0008177)succinate dehydrogenase (quinone) activity (GO:0008177)succinate metabolic process (GO:0006105)tricarboxylic acid cycle (GO:0006099)tricarboxylic acid cycle (GO:0006099)tricarboxylic acid cycle (GO:0006099)ubiquinone binding (GO:0048039)

Expression (TPM)

TFs regulating SDHB 0 TFs

Transcription factors with Perturb-seq knockdown data for SDHB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SDHB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SDHB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SDHB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:16,872,473–16,872,975	181.5 kb	Distal (>10kb) Multiome	52
chr1:16,888,814–16,889,966	164.6 kb	Distal (>10kb) Multiome	224
chr1:16,895,953–16,897,630	157.8 kb	Distal (>10kb) Multiome	749
chr1:16,903,833–16,905,921	149.1 kb	Distal (>10kb) Multiome	1065
chr1:16,913,177–16,914,707	140.1 kb	Distal (>10kb) Multiome	712
chr1:16,921,360–16,922,846	132.3 kb	Distal (>10kb) Multiome	315
chr1:16,938,744–16,939,855	114.9 kb	Distal (>10kb) Multiome	81
chr1:16,960,652–16,961,242	93.2 kb	Distal (>10kb) Multiome	417
chr1:16,980,463–16,980,871	73.6 kb	Distal (>10kb) Multiome	187
chr1:17,011,200–17,012,363	42.2 kb	Distal (>10kb) Multiome	573
chr1:17,053,525–17,054,572	22 bp	At TSS Multiome	770
chr1:17,059,691–17,059,939	5.6 kb	Proximal (<10kb)	216
chr1:17,119,233–17,119,812	65.4 kb	Distal (>10kb) Multiome	289

Genome Browser

Genomic view of the SDHB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.