The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TSG101. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSG101 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSG101, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,318,016–18,318,522 | 208.7 kb | Distal (>10kb) Multiome | 49 | |
| chr11:18,321,766–18,322,926 | 204.6 kb | Distal (>10kb) Multiome | 1044 | |
| chr11:18,393,759–18,396,665 | 130.7 kb | Distal (>10kb) Multiome | 1203 | |
| chr11:18,526,292–18,527,325 | 48 bp | At TSS Multiome | 1012 | |
| chr11:18,588,293–18,589,047 | 61.8 kb | Distal (>10kb) Multiome | 837 | |
| chr11:18,633,863–18,635,078 | 107.6 kb | Distal (>10kb) Multiome | 834 | |
| chr11:18,698,354–18,699,356 | 171.8 kb | Distal (>10kb) Multiome | 586 | |
| chr11:18,720,706–18,722,495 | 194.4 kb | Distal (>10kb) Multiome | 447 | |
| chr11:18,790,876–18,792,822 | 264.9 kb | Distal (>10kb) Multiome | 294 |
Genomic view of the TSG101 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.