The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BAK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:33,288,941–33,289,881 | 290.9 kb | Distal (>10kb) Multiome | 701 | |
| chr6:33,297,445–33,300,232 | 282.4 kb | Distal (>10kb) Multiome | 1095 | |
| chr6:33,312,436–33,314,207 | 267.4 kb | Distal (>10kb) Multiome | 795 | |
| chr6:33,317,189–33,318,504 | 262.4 kb | Distal (>10kb) Multiome | 649 | |
| chr6:33,322,636–33,323,832 | 257.1 kb | Distal (>10kb) Multiome | 941 | |
| chr6:33,346,609–33,347,126 | 233.5 kb | Distal (>10kb) Multiome | 37 | |
| chr6:33,390,888–33,392,247 | 188.7 kb | Distal (>10kb) Multiome | 993 | |
| chr6:33,409,936–33,411,502 | 169.8 kb | Distal (>10kb) Multiome | 977 | |
| chr6:33,417,606–33,419,249 | 162.0 kb | Distal (>10kb) Multiome | 973 | |
| chr6:33,419,793–33,420,532 | 160.1 kb | Distal (>10kb) Multiome | 162 | |
| chr6:33,425,590–33,426,362 | 154.4 kb | Distal (>10kb) Multiome | 665 | |
| chr6:33,431,024–33,432,096 | 149.1 kb | Distal (>10kb) Multiome | 337 | |
| chr6:33,454,074–33,454,852 | 125.8 kb | Distal (>10kb) Multiome | 906 | |
| chr6:33,547,185–33,548,324 | 32.6 kb | Distal (>10kb) Multiome | 155 | |
| chr6:33,570,899–33,571,638 | 8.9 kb | Proximal (<10kb) Multiome | 755 | |
| chr6:33,579,935–33,580,700 | 17 bp | At TSS Multiome | 639 | |
| chr6:33,585,697–33,586,103 | 5.4 kb | Proximal (<10kb) | 507 | |
| chr6:33,589,729–33,589,936 | 9.5 kb | Proximal (<10kb) | 328 | |
| chr6:33,592,764–33,593,449 | 12.7 kb | Distal (>10kb) Multiome | 224 | |
| chr6:33,620,828–33,622,474 | 41.8 kb | Distal (>10kb) Multiome | 594 | |
| chr6:33,632,607–33,634,721 | 52.4 kb | Distal (>10kb) Multiome | 600 | |
| chr6:33,711,017–33,712,173 | 131.4 kb | Distal (>10kb) Multiome HiCAR | 943 | |
| chr6:33,771,283–33,772,101 | 191.5 kb | Distal (>10kb) Multiome | 478 | |
| chr6:33,788,007–33,789,360 | 208.9 kb | Distal (>10kb) Multiome | 999 | |
| chr6:33,828,845–33,829,529 | 248.7 kb | Distal (>10kb) Multiome | 97 |
Genomic view of the BAK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.