DE-1

DE-1.26

Submodule 17 genes

Apoptosis and cell cycle regulation pathway

This module contains 17 genes including BAX, CDK4, TUBG1, UBE2M, and VPS29, with enrichment in apoptosis and cell cycle processes. Knockdown of ZC3H3, SOX17, and PREB activates this module. Knockdown of CTBP1 represses this module.

Notable genes: BAX CDK4 TUBG1 UBE2M VPS29 PGP AKR7A2 CENPX Top TFs: ZC3H3 SOX17 CTBP1 PREB

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (17)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z