The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for AKR7A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AKR7A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AKR7A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:19,209,669–19,210,758 | 101.8 kb | Distal (>10kb) Multiome | 990 | |
| chr1:19,251,426–19,252,084 | 60.4 kb | Distal (>10kb) Multiome | 930 | |
| chr1:19,311,493–19,312,976 | 110 bp | At TSS Multiome | 868 | |
| chr1:19,338,257–19,338,718 | 26.4 kb | Distal (>10kb) Multiome | 426 | |
| chr1:19,484,474–19,486,386 | 173.6 kb | Distal (>10kb) Multiome | 809 | |
| chr1:19,596,392–19,597,600 | 284.9 kb | Distal (>10kb) Multiome | 888 | |
| chr1:19,640,074–19,641,053 | 328.5 kb | Distal (>10kb) Multiome HiCAR | 418 | |
| chr1:19,643,702–19,645,210 | 332.1 kb | Distal (>10kb) Multiome HiCAR | 427 | |
| chr1:19,653,578–19,654,269 | 341.9 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr1:19,659,723–19,660,209 | 347.9 kb | Distal (>10kb) Multiome HiCAR | 316 |
Genomic view of the AKR7A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.