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DE-1.25

Submodule 17 genes

Mitochondrial function and redox homeostasis

This module contains 17 genes including PRDX3, YWHAB, ITGAE, MACROH2A1, and NDUFV2, with enrichment in mitochondrial oxidative phosphorylation and antioxidant responses. Knockdown of PREB represses this module, suggesting PREB supports the expression of these genes during endoderm differentiation.

Key terms: regulation of transcription by RNA polymerase I transcription by RNA polymerase I regulation of transcription of nucleolar large rRNA by RNA polymerase I nucleolar large rRNA transcription by RNA polymerase I Notable genes: PRDX3 YWHAB ITGAE MACROH2A1 NDUFV2 AIMP2 GLRX5 LYAR Top TFs: PREB

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (17)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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