This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for GLRX5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GLRX5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GLRX5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:95,291,132–95,291,627 | 243.7 kb | Distal (>10kb) Multiome | 174 | |
| chr14:95,319,274–95,320,393 | 215.2 kb | Distal (>10kb) Multiome | 440 | |
| chr14:95,514,691–95,515,550 | 20.0 kb | Distal (>10kb) Multiome | 307 | |
| chr14:95,516,090–95,517,032 | 18.6 kb | Distal (>10kb) Multiome | 555 | |
| chr14:95,534,312–95,535,544 | 201 bp | At TSS Multiome | 854 | |
| chr14:95,714,059–95,714,626 | 179.2 kb | Distal (>10kb) Multiome | 151 | |
| chr14:96,038,923–96,040,144 | 504.3 kb | Distal (>10kb) Multiome HiCAR | 440 |
Genomic view of the GLRX5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.