This gene encodes a mitochondrial protein with antioxidant function. The protein is similar to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase, and it can rescue bacterial resistance to alkylhydroperoxide in E. coli that lack the C22 subunit. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologs suggest that these genes consist of a family that is responsible for the regulation of cellular proliferation, differentiation and antioxidant functions. This family member can protect cells from oxidative stress, and it can promote cell survival in prostate cancer. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 3, 13 and 22. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for PRDX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,022,769–119,023,594 | 155.6 kb | Distal (>10kb) Multiome | 196 | |
| chr10:119,028,784–119,030,985 | 149.3 kb | Distal (>10kb) Multiome | 776 | |
| chr10:119,080,039–119,081,458 | 97.9 kb | Distal (>10kb) Multiome | 953 | |
| chr10:119,092,145–119,092,653 | 86.4 kb | Distal (>10kb) Multiome | 103 | |
| chr10:119,103,400–119,104,998 | 74.7 kb | Distal (>10kb) Multiome | 607 | |
| chr10:119,140,467–119,141,205 | 37.8 kb | Distal (>10kb) Multiome | 164 | |
| chr10:119,165,095–119,166,223 | 13.2 kb | Distal (>10kb) Multiome | 815 | |
| chr10:119,174,180–119,174,409 | 4.4 kb | Proximal (<10kb) | 27 | |
| chr10:119,178,426–119,179,231 | 43 bp | At TSS Multiome | 801 | |
| chr10:119,206,342–119,208,274 | 28.6 kb | Distal (>10kb) Multiome | 780 |
Genomic view of the PRDX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.