This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for YWHAB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YWHAB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YWHAB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,609,775–44,610,281 | 275.6 kb | Distal (>10kb) Multiome | 727 | |
| chr20:44,642,246–44,643,140 | 243.0 kb | Distal (>10kb) Multiome | 469 | |
| chr20:44,651,099–44,652,334 | 233.9 kb | Distal (>10kb) Multiome | 641 | |
| chr20:44,745,652–44,746,316 | 139.8 kb | Distal (>10kb) Multiome | 321 | |
| chr20:44,810,403–44,810,885 | 75.2 kb | Distal (>10kb) Multiome | 181 | |
| chr20:44,884,968–44,886,235 | 134 bp | At TSS Multiome | 913 | |
| chr20:44,909,510–44,910,396 | 24.3 kb | Distal (>10kb) Multiome | 810 | |
| chr20:44,911,292–44,911,995 | 26.0 kb | Distal (>10kb) Multiome | 532 | |
| chr20:44,960,068–44,960,912 | 74.8 kb | Distal (>10kb) Multiome | 1025 | |
| chr20:44,966,035–44,967,090 | 80.8 kb | Distal (>10kb) Multiome | 1001 | |
| chr20:45,098,253–45,098,840 | 212.9 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the YWHAB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.