Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ITGAE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGAE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGAE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:3,529,956–3,530,848 | 193.4 kb | Distal (>10kb) Multiome | 320 | |
| chr17:3,535,341–3,536,205 | 188.2 kb | Distal (>10kb) Multiome | 356 | |
| chr17:3,546,350–3,546,812 | 177.2 kb | Distal (>10kb) Multiome | 106 | |
| chr17:3,635,650–3,637,225 | 87.4 kb | Distal (>10kb) Multiome | 866 | |
| chr17:3,667,393–3,669,475 | 55.2 kb | Distal (>10kb) Multiome | 949 | |
| chr17:3,723,432–3,724,429 | 14 bp | At TSS Multiome | 865 | |
| chr17:3,754,197–3,755,835 | 31.1 kb | Distal (>10kb) Multiome | 396 | |
| chr17:3,845,518–3,846,549 | 122.5 kb | Distal (>10kb) Multiome | 917 | |
| chr17:3,891,925–3,893,745 | 169.4 kb | Distal (>10kb) Multiome | 716 | |
| chr17:3,944,497–3,945,384 | 221.1 kb | Distal (>10kb) Multiome | 277 | |
| chr17:3,964,969–3,965,418 | 241.4 kb | Distal (>10kb) Multiome | 333 | |
| chr17:4,003,950–4,004,421 | 280.1 kb | Distal (>10kb) Multiome | 404 | |
| chr17:4,004,672–4,005,109 | 281.0 kb | Distal (>10kb) Multiome | 632 |
Genomic view of the ITGAE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.