The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for AIMP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AIMP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AIMP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,781,073–5,781,919 | 227.6 kb | Distal (>10kb) Multiome | 696 | |
| chr7:5,822,727–5,823,386 | 186.2 kb | Distal (>10kb) Multiome | 650 | |
| chr7:6,008,669–6,009,907 | 59 bp | At TSS Multiome | 1068 | |
| chr7:6,058,614–6,059,749 | 49.9 kb | Distal (>10kb) Multiome | 916 | |
| chr7:6,081,109–6,081,851 | 72.3 kb | Distal (>10kb) Multiome | 904 | |
| chr7:6,103,982–6,105,662 | 95.5 kb | Distal (>10kb) Multiome | 1040 | |
| chr7:6,271,933–6,273,059 | 263.4 kb | Distal (>10kb) Multiome | 582 | |
| chr7:6,348,284–6,349,527 | 339.7 kb | Distal (>10kb) Multiome HiCAR | 787 |
Genomic view of the AIMP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.