This module contains 19 genes including PCBP2, TMEM230, M6PR, RNF5, and CMTM6, enriched for RNA binding, protein ubiquitination, and endosomal transport functions. Knockdown of FOXA2 activates this module, while knockdown of SOX17 represses it. This suggests coordinated regulation of post-transcriptional and protein trafficking processes during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.