This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CMTM6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CMTM6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CMTM6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:32,237,938–32,239,504 | 264.1 kb | Distal (>10kb) Multiome | 757 | |
| chr3:32,391,537–32,392,862 | 110.9 kb | Distal (>10kb) Multiome | 743 | |
| chr3:32,401,271–32,402,070 | 101.0 kb | Distal (>10kb) Multiome | 697 | |
| chr3:32,410,258–32,411,225 | 91.9 kb | Distal (>10kb) Multiome | 187 | |
| chr3:32,459,983–32,460,759 | 42.5 kb | Distal (>10kb) Multiome | 287 | |
| chr3:32,467,571–32,468,117 | 34.9 kb | Distal (>10kb) Multiome | 389 | |
| chr3:32,502,116–32,503,121 | 122 bp | At TSS Multiome | 723 | |
| chr3:32,510,223–32,510,402 | 7.4 kb | Proximal (<10kb) | 213 | |
| chr3:32,569,852–32,571,425 | 68.1 kb | Distal (>10kb) Multiome | 915 | |
| chr3:32,603,070–32,603,802 | 100.6 kb | Distal (>10kb) Multiome | 180 | |
| chr3:32,643,387–32,643,863 | 140.8 kb | Distal (>10kb) Multiome HiCAR | 118 | |
| chr3:32,684,803–32,685,731 | 182.4 kb | Distal (>10kb) Multiome HiCAR | 954 | |
| chr3:32,780,031–32,781,873 | 278.2 kb | Distal (>10kb) Multiome HiCAR | 958 |
Genomic view of the CMTM6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.