This gene encodes a multi-pass transmembrane protein that belongs to the TMEM134/TMEM230 protein family. The encoded protein localizes to secretory and recycling vesicle in the neuron and may be involved in synaptic vesicles trafficking and recycling. Mutations in this gene may be linked to familial Parkinson's disease. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for TMEM230. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM230 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM230, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:4,822,174–4,824,353 | 289.4 kb | Distal (>10kb) Multiome | 588 | |
| chr20:4,912,668–4,913,330 | 200.1 kb | Distal (>10kb) Multiome | 53 | |
| chr20:5,000,957–5,002,039 | 111.5 kb | Distal (>10kb) Multiome | 553 | |
| chr20:5,112,796–5,113,601 | 112 bp | At TSS Multiome | 1034 | |
| chr20:5,119,153–5,120,492 | 6.9 kb | Proximal (<10kb) Multiome | 1100 | |
| chr20:5,126,122–5,128,043 | 13.7 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:5,315,859–5,317,317 | 203.7 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the TMEM230 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.