MTDH

metadherin | 3D3, AEG-1, LYRIC

Enables NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in several processes, including lipopolysaccharide-mediated signaling pathway; positive regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Located in endoplasmic reticulum; nuclear lumen; and perinuclear region of cytoplasm. Implicated in hepatocellular carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.14 Developmental clusters: GC1

Biological processes 37 terms

NF-kappaB binding (GO:0051059)NF-kappaB binding (GO:0051059)RNA binding (GO:0003723)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)apical plasma membrane (GO:0016324)bicellular tight junction (GO:0005923)bicellular tight junction (GO:0005923)cytoplasm (GO:0005737)double-stranded RNA binding (GO:0003725)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)intercellular canaliculus (GO:0046581)lipopolysaccharide-mediated signaling pathway (GO:0031663)mRNA catabolic process (GO:0006402)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nuclear membrane (GO:0031965)nucleolus (GO:0005730)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of angiogenesis (GO:0045766)positive regulation of angiogenesis (GO:0045766)positive regulation of autophagy (GO:0010508)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)transcription coactivator activity (GO:0003713)transcription coregulator activity (GO:0003712)

Expression (TPM)

TFs regulating MTDH 0 TFs

Transcription factors with Perturb-seq knockdown data for MTDH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MTDH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MTDH

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MTDH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:96,261,159–96,263,004	1382.5 kb	Distal (>10kb) Multiome HiCAR	1100
chr8:97,643,510–97,645,718	49 bp	At TSS Multiome	951
chr8:97,700,751–97,701,322	9.7 kb	Proximal (<10kb)	19
chr8:97,761,283–97,761,890	117.5 kb	Distal (>10kb) Multiome	88
chr8:97,774,820–97,776,789	131.5 kb	Distal (>10kb) Multiome	1013
chr8:97,778,238–97,780,015	134.5 kb	Distal (>10kb) Multiome	400
chr8:97,781,999–97,784,345	139.4 kb	Distal (>10kb) Multiome	298
chr8:97,868,488–97,870,075	225.3 kb	Distal (>10kb) Multiome	498
chr8:97,932,331–97,934,476	289.6 kb	Distal (>10kb) Multiome	228

Genome Browser

Genomic view of the MTDH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.