Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in cytoplasmic stress granule. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EIF3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:1,368,617–1,369,820 | 985.6 kb | Distal (>10kb) Multiome HiCAR | 421 | |
| chr7:2,232,261–2,233,424 | 122.0 kb | Distal (>10kb) Multiome HiCAR | 809 | |
| chr7:2,241,746–2,242,506 | 112.7 kb | Distal (>10kb) Multiome HiCAR | 794 | |
| chr7:2,313,875–2,314,819 | 40.4 kb | Distal (>10kb) Multiome | 684 | |
| chr7:2,353,760–2,355,437 | 213 bp | At TSS Multiome | 1060 | |
| chr7:2,403,048–2,404,583 | 48.7 kb | Distal (>10kb) Multiome | 775 | |
| chr7:2,451,319–2,452,043 | 96.7 kb | Distal (>10kb) Multiome | 660 | |
| chr7:2,518,679–2,520,557 | 164.8 kb | Distal (>10kb) Multiome | 567 | |
| chr7:2,555,131–2,556,097 | 200.9 kb | Distal (>10kb) Multiome | 772 | |
| chr7:2,558,641–2,559,572 | 204.2 kb | Distal (>10kb) Multiome | 669 | |
| chr7:2,631,170–2,632,859 | 276.9 kb | Distal (>10kb) Multiome | 658 | |
| chr7:2,646,545–2,647,390 | 292.2 kb | Distal (>10kb) Multiome | 245 |
Genomic view of the EIF3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.