The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. [provided by RefSeq, May 2011]
Transcription factors with Perturb-seq knockdown data for CXADR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CXADR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CXADR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:17,436,486–17,437,621 | 76.1 kb | Distal (>10kb) Multiome | 197 | |
| chr21:17,454,250–17,455,351 | 58.2 kb | Distal (>10kb) Multiome | 838 | |
| chr21:17,492,445–17,493,147 | 20.3 kb | Distal (>10kb) Multiome | 199 | |
| chr21:17,512,112–17,514,078 | 161 bp | At TSS Multiome | 821 | |
| chr21:17,514,188–17,514,393 | 1.1 kb | Proximal (<10kb) | 200 | |
| chr21:17,611,431–17,613,632 | 99.9 kb | Distal (>10kb) Multiome | 814 |
Genomic view of the CXADR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.