The protein encoded by this gene contains a zinc finger SWI2/SNF2 and MuDR (SWIM) domain. Proteins with SWIM domains have been found in a diverse number of species and are predicted to interact with DNA or proteins. Mutations in this gene result in acromelic frontonasal dysostosis. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for ZSWIM6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSWIM6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSWIM6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:61,161,875–61,163,757 | 169.8 kb | Distal (>10kb) Multiome | 985 | |
| chr5:61,168,830–61,169,511 | 163.1 kb | Distal (>10kb) Multiome | 120 | |
| chr5:61,289,226–61,290,050 | 42.8 kb | Distal (>10kb) Multiome | 194 | |
| chr5:61,308,730–61,309,558 | 23.1 kb | Distal (>10kb) Multiome | 77 | |
| chr5:61,310,974–61,311,527 | 21.0 kb | Distal (>10kb) Multiome | 145 | |
| chr5:61,327,789–61,328,233 | 4.0 kb | Proximal (<10kb) | 232 | |
| chr5:61,328,901–61,329,369 | 2.9 kb | Proximal (<10kb) | 77 | |
| chr5:61,330,246–61,334,009 | 275 bp | At TSS Multiome | 953 | |
| chr5:61,408,527–61,409,188 | 76.6 kb | Distal (>10kb) Multiome | 781 | |
| chr5:61,625,646–61,626,958 | 293.8 kb | Distal (>10kb) Multiome | 354 |
Genomic view of the ZSWIM6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.