Predicted to enable zinc ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF428. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF428 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF428, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:43,463,046–43,464,465 | 156.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,474,993–43,475,696 | 144.3 kb | Distal (>10kb) Multiome | 506 | |
| chr19:43,503,542–43,505,032 | 115.4 kb | Distal (>10kb) Multiome | 760 | |
| chr19:43,526,489–43,527,639 | 92.4 kb | Distal (>10kb) Multiome | 712 | |
| chr19:43,532,595–43,534,553 | 85.5 kb | Distal (>10kb) Multiome | 698 | |
| chr19:43,575,342–43,576,244 | 44.0 kb | Distal (>10kb) Multiome | 562 | |
| chr19:43,580,271–43,581,020 | 39.0 kb | Distal (>10kb) Multiome | 151 | |
| chr19:43,594,710–43,596,874 | 23.3 kb | Distal (>10kb) Multiome | 998 | |
| chr19:43,618,905–43,620,391 | 142 bp | At TSS Multiome | 1071 | |
| chr19:43,623,946–43,624,138 | 4.3 kb | Proximal (<10kb) | 74 | |
| chr19:43,624,933–43,625,239 | 5.3 kb | Proximal (<10kb) | 185 | |
| chr19:43,639,490–43,640,467 | 20.2 kb | Distal (>10kb) Multiome | 545 | |
| chr19:43,667,574–43,669,430 | 49.0 kb | Distal (>10kb) Multiome | 787 | |
| chr19:43,671,889–43,672,687 | 52.6 kb | Distal (>10kb) Multiome | 162 | |
| chr19:43,673,253–43,674,111 | 54.2 kb | Distal (>10kb) Multiome | 55 | |
| chr19:43,754,239–43,755,900 | 135.1 kb | Distal (>10kb) Multiome | 899 | |
| chr19:43,773,845–43,774,908 | 154.9 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,798,557–43,799,046 | 179.2 kb | Distal (>10kb) Multiome | 403 | |
| chr19:43,827,133–43,827,702 | 207.7 kb | Distal (>10kb) Multiome | 593 | |
| chr19:43,901,409–43,901,966 | 282.2 kb | Distal (>10kb) Multiome | 528 |
Genomic view of the ZNF428 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.