Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF253. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF253 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF253, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,575,151–19,576,000 | 290.3 kb | Distal (>10kb) Multiome | 128 | |
| chr19:19,618,285–19,619,315 | 247.1 kb | Distal (>10kb) Multiome | 414 | |
| chr19:19,627,596–19,629,138 | 237.4 kb | Distal (>10kb) Multiome | 543 | |
| chr19:19,637,337–19,638,344 | 228.2 kb | Distal (>10kb) Multiome | 153 | |
| chr19:19,643,155–19,644,142 | 222.1 kb | Distal (>10kb) Multiome | 595 | |
| chr19:19,663,091–19,664,414 | 202.0 kb | Distal (>10kb) Multiome HiCAR | 848 | |
| chr19:19,668,196–19,669,404 | 197.1 kb | Distal (>10kb) Multiome HiCAR | 778 | |
| chr19:19,732,628–19,733,489 | 132.8 kb | Distal (>10kb) Multiome | 701 | |
| chr19:19,775,960–19,777,126 | 89.3 kb | Distal (>10kb) Multiome | 738 | |
| chr19:19,860,773–19,861,447 | 4.7 kb | Proximal (<10kb) Multiome | 112 | |
| chr19:19,865,643–19,866,347 | 15 bp | At TSS Multiome | 685 | |
| chr19:19,866,439–19,867,170 | 1.1 kb | Proximal (<10kb) Multiome | 306 | |
| chr19:19,900,670–19,901,891 | 35.0 kb | Distal (>10kb) Multiome | 405 | |
| chr19:20,038,984–20,039,716 | 173.6 kb | Distal (>10kb) Multiome | 495 | |
| chr19:20,051,726–20,052,860 | 186.3 kb | Distal (>10kb) Multiome | 402 | |
| chr19:20,066,768–20,067,242 | 201.1 kb | Distal (>10kb) Multiome | 8 | |
| chr19:20,067,957–20,069,262 | 203.1 kb | Distal (>10kb) Multiome | 17 | |
| chr19:20,077,737–20,078,423 | 212.1 kb | Distal (>10kb) Multiome | 212 | |
| chr19:20,082,410–20,083,233 | 217.0 kb | Distal (>10kb) Multiome | 155 |
Genomic view of the ZNF253 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.