Predicted to enable metal ion binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB8OS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB8OS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB8OS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:32,351,055–32,352,355 | 299.1 kb | Distal (>10kb) Multiome | 944 | |
| chr1:32,361,365–32,362,459 | 288.4 kb | Distal (>10kb) Multiome | 305 | |
| chr1:32,393,928–32,395,356 | 256.0 kb | Distal (>10kb) Multiome | 930 | |
| chr1:32,437,702–32,438,502 | 212.3 kb | Distal (>10kb) Multiome | 85 | |
| chr1:32,439,697–32,440,223 | 210.6 kb | Distal (>10kb) Multiome | 40 | |
| chr1:32,464,697–32,465,552 | 185.5 kb | Distal (>10kb) Multiome | 408 | |
| chr1:32,500,363–32,501,049 | 149.8 kb | Distal (>10kb) Multiome | 540 | |
| chr1:32,520,498–32,520,989 | 129.8 kb | Distal (>10kb) Multiome | 384 | |
| chr1:32,539,285–32,540,081 | 110.8 kb | Distal (>10kb) Multiome | 434 | |
| chr1:32,540,505–32,541,033 | 109.7 kb | Distal (>10kb) Multiome | 172 | |
| chr1:32,611,983–32,612,668 | 38.2 kb | Distal (>10kb) Multiome | 560 | |
| chr1:32,643,807–32,644,727 | 6.3 kb | Proximal (<10kb) Multiome | 70 | |
| chr1:32,650,248–32,651,874 | 483 bp | At TSS Multiome | 1164 | |
| chr1:32,712,054–32,712,688 | 61.8 kb | Distal (>10kb) Multiome | 645 | |
| chr1:32,715,926–32,717,303 | 66.2 kb | Distal (>10kb) Multiome | 551 | |
| chr1:32,736,558–32,737,765 | 86.5 kb | Distal (>10kb) Multiome | 507 | |
| chr1:32,753,606–32,755,507 | 103.4 kb | Distal (>10kb) Multiome | 565 | |
| chr1:32,758,502–32,759,280 | 108.3 kb | Distal (>10kb) Multiome | 144 | |
| chr1:32,765,137–32,765,925 | 115.2 kb | Distal (>10kb) Multiome | 122 | |
| chr1:32,772,938–32,773,451 | 122.6 kb | Distal (>10kb) Multiome | 441 | |
| chr1:32,816,876–32,818,654 | 167.0 kb | Distal (>10kb) Multiome | 1138 | |
| chr1:32,870,570–32,871,148 | 220.2 kb | Distal (>10kb) Multiome | 182 | |
| chr1:32,886,388–32,887,030 | 236.1 kb | Distal (>10kb) Multiome | 917 | |
| chr1:32,892,705–32,893,946 | 242.6 kb | Distal (>10kb) Multiome | 444 | |
| chr1:32,901,143–32,901,775 | 250.9 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the ZBTB8OS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.